New Step by Step Map For Promethazine With Codeine
New Step by Step Map For Promethazine With Codeine
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The phosphate salt of codeine takes place as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and somewhat soluble in Alcoholic beverages. The molecular pounds is 406.37. Its molecular formula is C18H21NO3•H3PO4 • ½ H2O, and it's got the next chemical composition.
Promethazine with Codeine Oral Solution is made up of promethazine, a phenothiazine. Phenothiazines are affiliated with dystonic reactions, particularly in pediatric people who may have an acute health issues affiliated with dehydration.
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The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers fewer than six many years of age, due to the fact the combination may well trigger fatal respiratory despair On this age inhabitants.
This medication can dry up and thicken mucus with your lungs, which makes it harder to breathe and distinct your lungs. That can help reduce this influence, consume plenty of fluids Until usually directed by your health care provider.
If this SPL consists of inactivated NDCs shown by the FDA initiated compliance action, they will be specified as a result.
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people less than 6 many years of age. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory melancholy, and at times death, in pediatric patients. The Affiliation does indirectly relate to individualized body weight-centered dosing, which might or else allow Risk-free administration.
Resulting from inconsistencies among the drug labels on DailyMed as well as the tablet photographs provided by RxImage, we no longer Display screen the RxImage capsule pictures associated with drug labels.
Ensure you know the way to consider this solution and what other medicines you should steer clear of taking with it. See also Drug Interactions section. Get health-related assist right away if any of those extremely critical Uncomfortable side effects arise: sluggish/shallow breathing, strange lightheadedness, extreme drowsiness/dizziness, issue waking up.
Due to the risk of respiratory melancholy, avoid the usage of opioid antitussives, together with Promethazine with Codeine Oral Option in sufferers with compromised respiratory perform, clients liable to respiratory failure, and in aged, cachectic, or debilitated sufferers.
Drug interactions may perhaps modify how your remedies perform or boost your danger for really serious Negative effects. This doc would not have all probable drug interactions.
Carcinogenicity scientific tests were being performed with promethazine hydrochloride. Two-yr scientific tests in F344/N rats and B6C3F1 mice click here were performed to assess the carcinogenic prospective of promethazine hydrochloride. No proof of tumorigenicity was observed in male and feminine rats at promethazine hydrochloride oral doses as many as 33 mg/kg/working day for five times/7 days (approximately similar to 10 situations the MRHD on a mg/m2 basis).
Promethazine is metabolized through the liver to many different inactive metabolites including sulfoxides of promethazine, N-demethylpromethazine along with other glucuronides.
Take into account that this medication has actually been prescribed due to the fact your physician has judged that the benefit for you is larger than the risk of Unwanted side effects. Many of us employing this medication would not have significant side effects.